Literature Highlights

Each week, we provide COVID-19 research article summaries and the main highlights in an infographic. Please come back weekly for more updated pandemic infographic highlights covering diagnosis, risk factors, treatment, and more.

  • Neutralizing capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel

  • Prevention and attenuation of COVID-19 with the BNT162b2 and mRNA-1273 vaccines

  • Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomized, controlled, open-label, platfom trial

  • Tackling COVID-19 with neutralizing monoclonal antibodies

  • Myocarditis following COVID-19 mRNA vaccination

  • Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicenter, randomized, controlled trial

  • 6-month consequences of COVID-19 in patients discharged from hospital: A cohort study

  • Interim Results of a Phase 1–2a Trial of Ad26.COV2.S COVID-19 Vaccine

  • ‘Long-COVID’: a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

  • Preliminary Findings of mRNA COVID-19 Vaccine Safety in Pregnant Persons

  • Tocilizumab in Patients Hospitalized with COVID-19 Pneumonia

  • Interleukin-6 Receptor Antagonists in Critically III Patients with COVID-19

  • Prospective Mapping of Viral Mutations That Escape Antibodies Used to Treat COVID-19

  • Early High-Titer Plasma Therapy to Prevent Severe COVID-19 in Older Adults

  • Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

  • Interim Results of a Phase 1-2a Trial of Ad26.COV2.S COVID-19 Vaccine

  • Baricitinib plus Remdesivir for Hospitalized Adults with COVID-19

  • Safety and Immunogenicity of an Inactivated SARS-CoV-2 Vaccine, BBIBP-CorV: A Randomized, Double-Blind, Placebo-Controlled, Phase 1/2 Trial

  • REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with COVID-19

  • Pre-pandemic Psychiatric Disorders and Risk of COVID-19: A UK Biobank Cohort Analysis

  • Baricitinib Therapy in COVID-19: A Pilot Study on Safety and Clinical Impact

  • SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with COVID-19

  • Safety and Immunogenicity of Two RNA-Based COVID-19 Vaccine Candidates

  • Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial

  • Therapeutic Versus Prophylactic Anticoagulation for Severe COVID-19: A Randomized Phase II Clinical Trial (HESACOVID)

  • Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

  • Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

  • Effects of COVID-19 on the Nervous System

  • COVID-19 Vaccine: A Comprehensive Status Report

  • Extrapulmonary Manifestations of COVID-19

  • Physical Distancing, Face Masks, and Eye Protection to Prevent Person-to-Person Transmission of SARS-CoV-2 and COVID-19: A Systematic Review and Meta-Analysis

  • Dexamethasone in Hospitalized Patients with COVID-19-Preliminary Report

  • Safety and Immunogenicity of the ChAdOx1 nCoV-19 Vaccine Against SARS-CoV-19: A Preliminary Report of a Phase 1/2, Single-Blind, Randomized Controlled Trial

  • An mRNA vaccine Aganist SARS-CoV-2 – Preliminary Report

  • Triple Combination of Interferon Beta-1b, Lopinavir-Ritonavir, and Ribavirin in the Treatment of Patients Admitted to Hospital With COVID-19: An Open-Label, Randomised, Phase 2 Trial

  • Pilot Prospective Open, Single-arm Multicentre Study on Off-label Use of Tocilizumab in Patients With Severe COVID-19

  • Observational Study of Hydroxychlaraquine in Hospitalized Patients with COVID-19

  • Clinical and Immunological Assessment of Asymptomatic SARS-CoV-2 Infections

  • Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital

  • Biomarkers Associated with COVID-19 Disease Progression

  • Remdesivir for the Treatment of COVID-19 – Preliminary Report

  • A Comparative Study on the Clinical Features of COVID-19 Pneumonia to Other Pneumonias

  • Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

  • Candidate drugs against SARS-CoV-2 and COVID-19

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Updates in the Treatment and Prevention of COVID-19​

Casirivimab and Imdevimab Approved in Japan for the Treatment of Mild-to-Moderate COVID-19

Japan’s Ministry of Health, Labour and Welfare (MHLW) has fully approved the combination of casirivimab and imdevimab to treat patients with mild-to-moderate COVID-19. This marks the first time a monoclonal-antibody cocktail has received full approval to treat COVID-19. This combination therapy is currently authorized for emergency use in more than 20 countries, including the United States, European Union, India, Switzerland, and Canada. The monoclonal antibody cocktail was approved in Japan after results from a phase 3 trial showed a 70% reduction in the risk of hospitalization or death in high-risk non-hospitalized patients who received casirivimab and imdevimab. The MHLW also reviewed results from a phase 1 trial that analyzed the safety, tolerability, and pharmacokinetics of the combination therapy in Japanese subjects. Multiple analyses have shown that casirivimab and imdevimab retain potency against circulating variants of concern, including Delta (B.1.162.2, first seen in India), Gamma (P.1, first seen in Brazil), and Beta (B.1.351, first seen in South Africa).

Reference

https://newsroom.regeneron.com/news-releases/news-release-details/japan-becomes-first-country-approve-regeneron-antibody-cocktail